Burns and Fire Disasters - vol. XIII - n° 1 - March 2000
NEW WHO BOOK
PRINCIPLES FOR THE ASSESSMENT OF RISKS TO
HUMAN HEALTH FROM EXPOSURE TO CHEMICALS
Criteria, No. 210
1999, xx + 110 pages (English, with summaries in French and Spanish)
ISBN 92 4 157210 8
Sw. fr. 29 / US $ 26.10 - In developing countries: Sw. fr. 20.30
This book provides a
state-of-the-art review of methods and procedures for assessing the risks to human health
posed by environmental chemicals. Addressed to regulatory authorities, risk managers, and
other decision-makers, the book aims to demystify the principles of risk assessment and
thus encourage wider use of this powerful tool for protecting populations.
Since the detection of chemical hazards may have socioeconomic and political consequences,
the book gives particular attention to methods for the accurate identification of risks
and determination of their severity. Details range from an alert to sources of uncertainty
in scientific evidence, through an explanation of the distinction between individual and
population risks, to a list of questions commonly addressed during risk characterization.
Practical advice on various options for risk elimination or reduction is also provided in
this comprehensive guide.
The book has four chapters covering each logical step in the process of risk assessment.
The first, on hazard identification, explains how data on a chemical's toxicity and mode
of action can be used to determine whether the chemical will cause adverse effects on
health. The strengths and limitations of different types of data are discussed together
with criteria commonly used to establish causality. Methods for assessing doseresponse
relationships are reviewed in chapter two, which explains how to characterize the
relationship between the dose administered or received and the incidence of an adverse
effect. Methods for assessing nonneoplastic, or threshold, effects and neoplastic,
non-threshold effects are described in detail.
Exposure assessment is covered in the next chapter, which describes methods for
determining the nature and extent of contact with chemical substances and discusses the
special characteristics of exposure in the general environment, in the workplace, and from
consumer products. The final chapter explains the procedure of risk characterization as a
decisionmaking tool that brings together estimates of exposure levels and risks and
summarizes sources of uncertainty in the scientific data. Practical options for risk
management are presented as a range of regulatory, nonregulatory, economic, advisory, and
SAFE MANAGEMENT OF
WASTES FROM HEALTH-CARE ACTIVITIES
Edited by A. Priiss, E. Giroult, and P. Rushbrook
1999, xiv + 230 pages + 4 colour plates (available in English; French and Spanish in
ISBN 92 4154 6298
Sw. Fr. 72 / US $ 64.80 - In developing countries Sw. Fir. 50.40 Order no. 1150458
WHO, Marketing and Dissemination,
CH-1211 Geneva 27, Switzerland
This handbook provides the
first comprehensive guide to the safe and efficient handling, treatment, and disposal of
all categories of hazardous waste generated by health-care activities. Although the major
emphasis is on waste generated by hospitals, guidelines and advice are also relevant to
wastes produced in health centres, research facilities, and laboratories or associated
with home care or treatment in doctors and dentists practices.
In publishing this handbook WHO aims not only to promote a sound managerial approach and
the use of appropriate technologies but also to inform countries about the health risks
that result from inadequate management of health-care waste. With these goals in mind, the
book provides both an alert to documented public health and environmental hazards and a
catalogue of the technical, managerial, and legislative options available for reducing
these risks. All components of a waste management policy - whether at national or
institutional level - are considered in detail.
Although recommended policies and procedures have universal relevance, the handbook gives
particular attention to conditions in developing countries, where methods for the safe
treatment and disposal of hazardous waste may be limited. With these conditions in mind,
the handbook includes approaches for gradual improvements together with a catalogue of
options for waste management that include both simple and highly sophisticated
technologies. Throughout, photographs, line drawings, checklists, tables, and step-by-step
procedures are used to enhance the wealth of guidance provided.
The book opens with a definition and characterization of hazardous health-care wastes
categorized as infectious waste, pathological waste, sharps, pharmaceutical waste,
genotoxic waste, chemical waste, waste with high content of heavy metals, pressurized
containers, and radioactive waste. The health consequences of exposure to each category of
waste are described in the next chapter, which concerns the nature and severity of
associated health hazards, factors influencing the likelihood of exposure, persons at
risk, and the significance for public health. Concentrated cultures of pathogens and
contaminated sharps are identified as the waste ,items that represent the most acute
potential hazards to health. Other chapters consider legislative, regulatory, and policy
issues and offer a step-by-step guide to the planning of waste management, including use
of a detailed model survey questionnaire for gathering data on waste generation and
management practices in hospitals.
Against this background, five chapters offer guidance in a range of specific practices and
procedures for safe waste management. Chapters cover strategies for waste minimization,
recycling, and re-use; good practices in the handling, segregation, packaging, storage,
and transportation of wastes; a wide range of treatment and disposal technologies;
treatment and disposal technologies appropriate for specific categories of waste; and the
collection and safe disposal of hazardous waste water. The remaining chapters discuss
costs, health and safety practices for health-care personnel and waste workers, the
management of spillage and other emergencies, basic principles of hospital hygiene and
infection control, and training needs. The final chapter sets out a minimum programme of
essential waste management practices considered suitable for smaller rural health care
establishments and field hospitals in refugee camps and other temporary situations.
RAPID HEALTH ASSESSMENT
PROTOCOLS FOR EMERGENCIES
1999, vi + 97 pages (available in English; French and Spanish in preparation)
ISBN 92 4 154515 1
Sw. fr. 31 / US $ 27.90 - in developing countries Sw. fr. 21.70 - Order No.
This book provides a
collection of ten protocols for conducting rapid health assessments in the immediate
aftermath of different types of emergencies. Noting the vital importance of rapid and
accurate information in the earliest stage of an emergency, the protocols respond to the
urgent need for common standardized technical tools for assessing damage, gauging health
risks, and gathering the information immediately needed by decision-makers at the national
and international level.
The protocols were prepared by WHO in collaboration with a large number of international
agencies and experts with broad experience in the field of emergency management. Although
all protocols follow a common format, each is specific to the circumstances, potential
hazards, and immediate information needs that characterize a distinct type of emergency.
Emphasis is placed on the exact information needed, the best sources of data and methods
for rapid collection, and the specific questions that need to be answered in order to draw
initial conclusions and direct immediate actions. Although the advantages of using
experienced assessments teams are stressed, the book also explains how the protocols can
be used to train general health workers as part of emergency preparedness.
The book opens with an introductory protocol covering the aims and methods,
responsibilities, complexities, and inherent difficulties of rapid health assessments.
Addressed to health authorities as well as assessment teams, the chapter also includes
abundant advice on preparedness for emergencies. Details range from the comparative need
for speed in different types of emergencies, through a suggested format for presenting the
results of assessments, to a list of common logistic, organizational, and technical
errors. Advice on the best working practices, including ways to avoid being an
"emergency tourist", is also provided.
Against this background, the additional nine protocols are presented according to a common
format which covers the purpose of the assessment, preparedness, the steps to follow
during the assessment, assessing the impact on health, assessing local response capacity
and immediate needs, and presenting results. A general protocol on epidemics of infectious
origin is followed by protocols specific to meningitis outbreaks, outbreaks of viral
haemorrhagic fever, including yellow fever, and outbreaks of acute diarrhoeal disease,
with information specific to dysentery and cholera.
Sudden-impact natural disasters are covered in the next protocol, which includes a
day-by-day list of information priorities for different stages of the disaster. A protocol
dealing with sudden population displacements offers guidelines for conducting rapid health
assessments in all emergencies caused by sudden displacement of refugees or population
groups within a country. Included are a sample checklist for rapid assessments and a
sample form for weekly reports on morbidity and mortality. Subsequent protocols deal with
the special situations of nutritional emergencies and chemical emergencies, including
those caused by food contaminated with chemicals or toxins. The final protocol addresses
the difficult task of conducting assessments in complex emergencies in which the cause of
the emergency, as well as the assistance to the afflicted, is complicated by intense
levels of political considerations. The protocol includes a form which has recently been
used for rapid health assessment at local level in Bosnia and Herzegovnia.
The book concludes with a brief summary of survey techniques, followed by a tabular
presentation of reference values for assessing needs, hazards, and logistic requirements,
in developing countries.
The MBC is WHO Collaborating Centre in the field of burns and fire disasters.
TRIS (CHLOROPROPYL) PHOSPATE
AND TRIS(2-CHLOROETHYL) PHOSPHATE
WHO Environmental Health Criteria, No. 209
1998, xix + 106 pages (English with summaries in French and Spanish)
ISBN 92 4 157209 4
Sw. fr. 27 / US $ 24.30 - In developing countries: Sw. fr. 18.90 - Order No. 1160209
This book evaluates the
risks to human health and the environment posed by exposure to three flame retardants:
tris(I-chloro-2-propyl) phosphate (TCPP), tris(1,3-dichloro-2-propyl) phosphate (TDCPP),
and tris(2-chloroethyl) phosphate (TCEP). In view of their many similarities, TCPP and
TDCPP are covered together. Data on all three flame retardants are extremely limited and
largely confined to studies of environmental levels and adverse effects detected in
experimental animals and in vitro test systems.
The monograph on TCPP and TDCPP describes manufacturing processes and summarizes current
uses. The vast majority of TCPP is used in rigid polyurethane foams, with main
applications in insulation for buildings and in refrigerator casings. TDCPP is likewise
added as a flame retardant to polyurethane foam and has some additional applications as a
flame retardant for non-woven fabrics. For both chemicals, studies show that residues are
found infrequently and at low concentrations in food items. For TCPP, traces have been
detected in industrial and domestic effluents but not in surface water or drinking-water.
Traces of TDCPP have been detected in sewage effluent, river water, seawater,
drinkingwater, and water sediment, and in fish. In view of the low volatility of both
chemicals, the report concludes that human exposure from these sources will be very low
and will not present an acute health hazard for the general population.
Likewise, no adverse effects on the environment are anticipated from the use of either of
these flame retardants.
Experimental studies of TCPP in laboratory animals demonstrate low to moderate toxicity by
the oral, dermal, and inhalation routes. Tests indicate that the chemical is neither a
skin nor an eye irritant. No studies were available to evaluate reproductive toxicity,
immunotoxicity, or carcinogenic potential. In vitro and in vivo mutagenicity
studies produced negative results.
Toxicity studies of TDCPP show low to moderate acute toxicity by the oral route and low
acute toxicity by the dermal route. The report found no evidence of teratogenicity or
mutagenicity. A single carcinogenicity study found an increased occurrence of several
turnouts at all exposure levels tested in both male and female rats. In the absence of
data on the mechanisms of carcinogenic action, the relevance of these findings to humans
could not be assessed. The limited studies of occupationally exposed workers were judged
inadequate for evaluation.
The second monograph evaluates TCEP, a flame retardant with declining uses in the
production of liquid polyester resins and in textile back-coating formulations. Traces
have been detected in river water, seawater, drinking-water, sediment, fish and shellfish,
and a few food items. Experimental studies show low to moderate acute oral toxicity. In
repeat dose experiments, TCEP caused adverse effects on the brain, liver, and kidneys. ne
report concludes that TCEP is not an irritant to the eye or skin and is not teratogenic,
although some adverse effects on the fertility of male rats and mice have been
demonstrated. Data indicating low environmental exposures support the conclusion that TCEP
poses a very low risk of adverse health effects for the general population. Use of TCEP is
not expected to cause any adverse effects on the environment.